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A common challenge in systems operating at higher voltage occurs during initial power-up with so-called “inrush” current, particularly when a significant capacitive load is part of the circuitry (though resistive and inductive issues are also important to consider and understand).
Inrush current has the potential to damage or at least stress components if not managed in some way. This basic situation is common in modern electric vehicles (EVs) that often operate at 400 V, with some now operating at 800 V.