Freeslate Inc., a provider of high-throughput research solutions for biopharmaceutical development, and Trinean NV, a provider of microfluidic spectrophotometry platforms, today announced the integration of the DropSense96 with the CM3 product line for biotherapeutics formulation and optimization.
Based on the CM3 automation platform, the Freeslate Biologics Formulation System offers high throughput formulation, stressing, and analysis. Integration of the DropSense96 provides CM3 users the ability to quickly determine protein concentration without dilution steps. This increases system accuracy and results in faster workflows.
“The full automation of the DropSense96 with Freeslate’s Biologics Formulation System allows users to dramatically increase the throughput of their analysis. The ability to prepare, stress, and analyze all in one workflow means greater efficiency and enhanced decision making for our users,” said Philippe Stas, CEO of Trinean. “Working together with the Freeslate teams to optimize the workflows has been very rewarding.”
“With a number of seamless integrations of the DropSense96 with our platform, we have selected the instrument as our preferred option for quantification of biologics,” said John S. Senaldi, president and CEO of Freeslate. “Its unique design combining speed, minimal sample usage, and an unmet measurement range allows for fast, yet robust quantification of protein samples thereby significantly shortening the screening process in biotherapeutic drug development.”
The Trinean DropSense96 UV/VIS droplet reader is designed for high throughput analysis of biological samples. Its unique microfluidic 96-well format allows for quantification of samples as small as t wo microliters in a fully automated workflow. The Trinean software toolbox is available fordetailed sample QC, workflow integration, and compliance in regulatory environments
Freeslate’s Lab Execution and Analysis (LEA) software seamlessly manages the entire experimental process from design and execution to data analysis and report sharing. It allows users to design complex experiments quickly using its logical, recipe-oriented approach, and experimental conditions can be linked to analytical data for easy viewing and reporting. Using LEA, third party equipment such as the DropSense96 plate reader, is fully integrated with Freeslate robotic components and sample data is directly linked to the processing steps and analytical results. Other standard integrations available with the Biologics Formulation System include fully automated third party instruments such as the dynamic light scatter reader, centrifuge, plate sealer, and shaking incubator and off-deck, semi-automated analytical instruments including UPLC, HPLC, cIEF,and cSDS.